If the Supreme Court makes it much more difficult to apply patent law with respect to software, it will affect smaller software companies disproportionately relative to larger companies. "Windows" was rejected by the USPTO many times (it was, after all, a generic term) - but MSFT ultimately won out because MSFT had enough resources (lawyers) available to stay the course indefinitely. Smaller companies may struggle.

Hey Brad, do you plan on tweeting during proceedings? That way, we can all attend...

"Zen" was a classic. The story behind it should be savored by entrepreneurs as well - Pirsig's book was rejected 121 times before is was finally published.

Lesson: Never give up. ;-)