wizrobe
92p24 comments posted · 4 followers · following 0
10 years ago @ Crasstalk - Friday Open Thread · 40 replies · +33 points
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10 years ago @ Crasstalk - Tuesday Open Thread · 0 replies · +2 points
10 years ago @ Crasstalk - Saturday Open Thread · 9 replies · +16 points
You can, but save your money and buy a better antihistamine.
Schering-Plough pulled a fast one when they succeeded in getting Claritin approved as a non-drowsy antihistamine; it really doesn't behave as one. What they did, was lower the dosage until somnolence effects were just a bit below statistical threshold, but efficacy was still just a little bit above. Of course, this means that the dosage cap is stuck at that point (else they would lose their non-drowsy indication).
From what I've heard, the US FDA reviewer in charge was younger and inexperienced, which is how this managed to get past them. I believe some other reviewers have suggested that dosages would need to be as high as 40mg to match the efficacy of older-generation antihistamines.
Of the OTC 2nd/3rd generation antihistamines (note: classification of generations is not very consistent across expert sources), I would say Allegra (fexofenadine) has the best combination of efficacy and non-sedating action; Zyrtec is pretty good but has some mild sedating effects.
Then there are the corticosteroid nasal sprays, and some unusual agents such as Mast Cell Stabilizers and Leukotriene Antagonists, as well as non-medicinal agents such as saline nasal washes and barrier gels. But those are topics for another post.
10 years ago @ Crasstalk - Saturday Open Thread · 7 replies · +22 points
10 years ago @ Crasstalk - Saturday Open Thread · 1 reply · +24 points
10 years ago @ Crasstalk - Saturday Open Thread · 5 replies · +31 points
I'm kind of new here, is that what you call your spouse?
10 years ago @ Crasstalk - The Ideologies of Wiza... · 0 replies · +6 points
10 years ago @ Crasstalk - The Ideologies of Wiza... · 4 replies · +6 points
10 years ago @ Crasstalk - The Ideologies of Wiza... · 2 replies · +12 points
10 years ago @ Crasstalk - The Ideologies of Wiza... · 3 replies · +8 points
I am allergic to eggs. :-)