I also used to suffer from the two-year itch, but I've been at my current job four years or so. I watched Amber bounce around from job-to-job after leaving the same place a few years ago. It didn't work out for her and she's back, which I think is a powerful testimonial that it's a better place to work than a lot of others. I would have to want to start my own company or be offered a truly extraordinary opportunity (like working on President Obama's web staff or something) to want to leave. At more places than not, a job is a job.