So the important thing to remember is that the EBS (Extended Blob Storage) takes the content out of the database. This makes the operational management easier to perform and content databases don't get large as fast. There is no usability differences in this case. Furthermore, many of the mainstream ECM vendors have integrated into the EBS API to facilitate the storage of the content directly into their Applications. While it does complicate the architecture, it allows the typical "storing blobs in the database" complaint to be mitigated.

Operationally, with native SQLServer tools, the "best practices" recommendation for content databases is 100Gb. With enterprise tools, these databases can be much larger as it depends on the comfort of the support organization.